The Steelers took advantage of a lackluster Cleveland offense, which turned the ball over five times and was sacked six times by the Pittsburgh defense.
Charlie Frye started at quarterback for the Browns and was pulled halfway through the second quarter in favor of backup Derek Anderson. Frye finished the day a paltry 4-of-10 passing for 34 yards, while throwing an interception early in the first quarter.
Following a Jamal Lewis fumble, Roethlisberger connected with second year wide receiver Santonio Holmes on a 40-yard touchdown pass to open up a 17-point lead, a deficit the Browns would never come close to matching.
Third round draft pick Matt Spaeth opened the third quarter by hauling in a 5-yard touchdown pass from Roethlisberger to increase the Steelers lead to 24-0. The play was not only the first touchdown of Spaeth's career, but the first catch as well.