Hampton will replace San Diego defensive tackle Jamal Williams, who will miss the game with an injury.
Hampton will be making his third straight trip to the NFL’s annual all-star game as one of the top defensive linemen in the league.
The Steelers first-round draft pick (19th overall) in the 2001 NFL Draft, Hampton helped Pittsburgh finish the 2007 regular season ranked first in the league in total defense, allowing just 266.4 yards per game.
Hampton will join three other teammates at the Pro Bowl, including starting offensive guard Alan Faneca and linebacker James Harrison. Quarterback Ben Roethlisberger will also be making his first trip to the all-star game as a backup.
Two Steelers will miss the game with injuries as running back Willie Parker and safety Troy Polamalu have declined invitations.